Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats.
- Author:
Pei-Fei GU
1
;
Dong-Ming GAO
;
Yu SHANG
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; Animals; Corpus Striatum; physiopathology; Disease Models, Animal; Electric Stimulation Therapy; Male; Neurons; physiology; Parkinson Disease; physiopathology; therapy; Rats; Rats, Sprague-Dawley; Subthalamic Nucleus
- From: Chinese Journal of Applied Physiology 2004;20(1):83-87
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo observe the change of STR neuronal firing rates with high frequency stimulation of subthalamic nucleus in PD rats.
METHODSA model of Parkinson's disease was induced by unilateral administration of 6-hydroxydopamine into right substantia nigra in rats. After the high-frequency stimulation to STN, the spontaneous firing rates of STR on normal and PD rats were recorded by using extracellular recordings.
RESULTSStimulation caused a direct excited effect of STR neurons in normal rats whereas a excited and inhibited effect in PD rats. The inhibited effect was correlated with the stimulation period (r = 0.94).
CONCLUSIONStimulation to STN may inhibit the spontaneous firing rates of STR neurons in PD rats. These results also give some clues that high-frequency stimulation to STN may be a effective therapy to the clinical treatment of Parkinson's disease.
