Study on improvement of output of semi-synthesis of artemether.
- Author:
Nghi Huu Do
- Publication Type:Journal Article
- Keywords:
artemether
- MeSH:
Artemether;
Pharmaceutical Preparations;
therapeutics;
malaria
- From:Pharmaceutical Journal
1999;282(10):7-9
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Beta-Artemether (12beta-O-menthyldihyroartemisinin), a potent antimalarial drug has been synthetised from dihydroartemisinin using nonpolar waterimmiscible solvents and boron trifluorid etherate as a catalyst. Using this methods we always obtain a mixture of beta and alpha artemether with the ratio from 3/1 to 4/1 and the yield of beta-artemether is about 60%. Using polar waterimmiscible solvents in place of nonpolar waterimmiscible solvents in the synthesis can improve the ratio of beta/alpha artemether to 20/1 and the yield of beta-artemether increase to about 70% beta-artemether.
