Expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and the clinicopathological implications.
- Author:
Xiufen LI
1
;
Anli HOU
;
Zhenhuan LI
;
Shuqin FANG
;
Yali ZHANG
;
Yawei XU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; metabolism; Female; Humans; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; metabolism; Lymphatic Metastasis; Proto-Oncogene Proteins; metabolism; Uterine Cervical Neoplasms; metabolism
- From: Journal of Southern Medical University 2015;35(7):1063-1067
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and explore the clinicopathological implications.
METHODSImmunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the expressions of SFRP4 and DKK1 in 66 cervical squamous cell carcinoma and 26 normal cervical specimens.
RESULTSSFRP4 expression was significantly higher (P<0.01) and DKK1 expression was significantly lower (P<0.05) in the carcinoma tissues than in normal cervical tissues. DKK1 was negatively correlated with SFRP4 in the carcinoma tissues (P<0.01), and their expressions were associated with the clinical stages, tumor differentiation, depth of invasion and lymph node metastasis of the tumors (P<0.05).
CONCLUSIONSFRP4 and DKK1, the upstream components of the Wnt pathway, play a key role in the tumorigenesis of cervical squamous cell carcinoma, and their expressions are associated with the clinicopathological features of the malignancy.
