Structural changes in the gray matter in patients with trigeminal neuralgia: a voxel-based morphometric study.
- Author:
Jianhao YAN
1
;
Meng LI
;
Tianyue WANG
;
Wenfeng ZHAN
;
Guihua JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Brain Mapping; Case-Control Studies; Frontal Lobe; pathology; Gray Matter; pathology; Humans; Magnetic Resonance Imaging; Temporal Lobe; pathology; Trigeminal Neuralgia; pathology
- From: Journal of Southern Medical University 2015;35(8):1180-1183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes in whole brain gray matter volume in patients with trigeminal neuralgia using voxel-based morphometry (VBM).
METHODSTwenty-eight patients with trigeminal neuralgia and 28 healthy controls underwent magnetic resonance imaging with a Philips 1.5T MRI scanner. VBM was used to compare the structural differences in the whole brain gray matter between the two groups based on the DARTEL after data preprocessing with SPM8 software package.
RESULTSCompared with the healthy controls, the patients with trigeminal neuralgia presented with decreased gray matter volume in several brain regions including the bilateral middle temporal gyrus, bilateral superior/middle frontal gyrus, left pre-/post-central gyrus, right fusiform and anterior cingulate gyrus.
CONCLUSIONSPatients with trigeminal neuralgia had abnormal gray matter volume in some brain regions associated with perception and processing of pain sensation. These changes may provide clues for further exploration of the neuropathogenic basis of trigeminal neuralgia.
