Does Heparin Reduce Neurologic Injury in Rabbits That Occurs From Air Emboli?.
10.4097/kjae.1997.33.4.604
- Author:
Keon Hee RYU
;
Cheol Joo PARK
;
Sung Nyeon KIM
;
Jong Ho CHO
;
Eun Sung KIM
;
Yoon Ki LEE
;
Young Ho HONG
;
Chang Sung KIM
- Publication Type:Original Article
- Keywords:
Animals, rabbit;
Brain, impairment;
Pharmacology, heparin;
Embolism, air
- MeSH:
Anesthesia;
Embolism, Air;
Endothelium;
Heparin*;
Rabbits*
- From:Korean Journal of Anesthesiology
1997;33(4):604-609
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Neurological injury after cerebral air embolism may be due to thromboinflammatory responses at sites of air-injured endothelium. Because heparin inhibits multiple thromboinflammatory processes. we hypothesized that heparin would decrease neurological impairment after cerebral air embolism. METHODS: Anesthetized rabbits received either heparin (n=14) or saline (n=13), 5 minutes before air injection (150 microliter/kg). Heparin was given as a 200 IU/kg bolus and followed by a constant infusion of 75 IU/kg/h for 2 hours. Equal volumes of salines were given to saline group. Two hours later, anesthesia was discontinued. Rabbits were neurologically evaluated 24 hours after air embolism. RESULTS: Heparin group had significantly less neurological impairment at 24 hours (34 14) than saline controls (52 8) (p=0.0013). CONCLUSIONS: When given prophylactically, heparin decreases neurological impairment caused by severe cerebral arterial air embolism.
