Impact of visit-to-visit blood pressure variability on vascular function in elderly hypertensive patients.
- Author:
Qiyun LIU
1
;
Yingying LIU
;
Junli HAN
;
Jianghua LI
;
Shaohong DONG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Blood Pressure; Brachial Artery; Endothelium, Vascular; physiopathology; Essential Hypertension; Humans; Hypertension; Multivariate Analysis; Nitroglycerin; Regression Analysis; Vasodilation
- From: Journal of Southern Medical University 2015;35(9):1320-1324
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the relationship between visit-to-visit blood pressure (BP) variability (BPV) and vascular endothelial function in a cohort of elderly hypertensive patients.
METHODSA total of 174 elderly patients with essential hypertension were included in the study. The participants had their office BP measured during the 12-month follow-up. Right brachial artery diameter was assessed at rest, during reactive hyperemia (flow-mediated dilation, FMD), and after nitroglycerin administration (nitroglycerin-mediated dilation, NMD). The participants were divided into two groups according to FMD% or FMD/NMD ratio. The correlations between BPV and endothelial function were analyzed by univariate analysis and multiple linear regression analysis.
RESULTSThe participants classified as having a decreased endothelial function according to FMD/NMD ratio had significantly lower FMD% and higher BPV and NMD% (P<0.05). The percentage of CCBs use in normal endothelial function group was significantly higher than that in decreased endothelial function group (79.55% vs 63.95%, P<0.05). Multiple linear regression analysis revealed a significant negative association between FMD/NMD ratio and BPV, and this association remained significant after adjustment for age, body mass index, and mean BP levels.
CONCLUSIONSFMD/NMD ratio is a better marker of endothelial function than FMD, and an increased visit-to-visit variability of BP is associated with a decreased endothelial function.