Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in Chinese Han population in Hainan Province.
- Author:
Xiang HUANG
1
;
Xunding QIU
;
Minglei SUN
;
Shengteng HE
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; Cell Cycle Proteins; genetics; Gene Frequency; Genotype; Humans; Parotid Neoplasms; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Transcription Factors; genetics; Tumor Suppressor Proteins; genetics
- From: Journal of Southern Medical University 2015;35(9):1360-1365
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province.
METHODSSixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing.
RESULTSOf the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30% in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05).
CONCLUSIONRs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.
