Longitudinal evaluation of reparative cartilage after matrix-associated autologous chondrocyte implantation with delayed gadolinium-enhanced MRI of the cartilage.
- Author:
Li-Sen ZHONG
1
;
Xian XU
;
Xue LI
;
Shao-Jun HAN
;
Jun ZHANG
;
Tian-Ming DONG
;
Pan-Li ZUO
;
Ning-Yu AN
Author Information
- Publication Type:Journal Article
- MeSH: Cartilage; pathology; Chondrocytes; transplantation; Gadolinium; Humans; Magnetic Resonance Imaging; Orthopedic Procedures
- From: Journal of Southern Medical University 2015;35(10):1467-1471
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo estimate zonal variation of GAG content in reparative cartilage after matrix associated autologous chondrocyte implantation (MACI) using delayed gadolinium-enhanced magnetic resonance imaging of the cartilage (dGEMRIC).
METHODSSeven patients (14 cartilage defects) undergoing MACI were recruited for examination with dGEMRIC at 3, 6, and 12 months after the procedure to calculate global and zonal longitudinal relaxivity (Δ R1) of the normal cartilage and reparative cartilage.
RESULTSThe mean Δ R1 values of normal cartilage were significantly lower than those of reparative cartilage after MACI. A significant decrease was noted in the mean Δ R1 values from the deep layer to the superficial layer in the reparative cartilage at the 3 examinations. The Δ R1 values of the reparative cartilage showed no significant variation between 3 months and 6 months, but a significant decrease in the Δ R1 values occurred at 12 months.
CONCLUSIONSdGEMRIC is feasible to assess cartilage repair noninvasively following MACI.
