Comparative Maternal and Neonatal Effects of Propofol, Propofol-Ketamine and Ketamine as Induction Agents in Cesarean Section.
10.4097/kjae.1997.33.4.653
- Author:
Hong Beum KIM
;
Seung Ho LEE
;
Myoung Keun SHIN
;
In Kyu KIM
;
Pil Oh SONG
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthetics, intravenous, propofol, ketamine;
Pregnancy, cesarean section
- MeSH:
Anesthesia;
Anesthesia, Intravenous;
Apgar Score;
Blood Gas Analysis;
Blood Pressure;
Cesarean Section*;
Depression;
Female;
Heart Rate;
Hemodynamics;
Humans;
Infant, Newborn;
Intubation;
Ketamine*;
Mothers;
Pregnancy;
Propofol*
- From:Korean Journal of Anesthesiology
1997;33(4):653-659
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Propofol and ketamine had been used for anesthesia induction and for total intravenous anesthesia. The nature of any hypnotic interactions occurring between propofol and ketamine are unknown. A comparison of maternal and neonatal effects among propofol-ketamine combination, ketamine and propofol were studied when used for anesthesia induction in Cesarean section. METHODS: Forty five patients in ASA class I or II scheduled for Cesarean section randomly assigned to either propofol 2 mg/kg (n=15), ketamine 1 mg/kg (n=15) or propofol 1 mg/kg - ketamine 0.5 mg/kg combination group (n=15) as an induction agent. Maternal systolic and diastolic blood pressure, heart rate, Apgar score and umbilical blood gas analysis were measured. RESULTS: Before intubation, systolic and diastolic pressure were decreased in propofol group but increased in ketamine and propofol-ketamine combination group. Heart rate were increased in all three groups. But there were no significant differences among three groups (p<0.05). After intubation, there were significant increase in systolic, diastolic pressure and heart rate in three groups but no significant differences among three groups (p<0.05). And there was no significant neonatal depression as assessed by Apgar scores and blood gas analyses. CONCLUSIONS: Propofol-ketamine combination was found to be similar to propofol or ketamine only in the effects on the mother and neonate. But propofol-ketamine gained more stable hemodynamic change than propofol or ketamine before intubation. Therefore propofol-ketamine appears to be a suitable alternatives to propofol or ketamine as an induction agent for anesthesia in Cesarean section.
