Partial liquid ventilation decreases tissue and serum tumor necrosis factor-α concentrations in acute lung injury model of immature piglet induced by oleic acid.
- Author:
Yao-Bin ZHU
1
;
Xiang-Ming FAN
;
Xiao-Feng LI
;
Zhi-Qiang LI
;
Qiang WANG
;
Li-Zhong SUN
;
Ying-Long LIU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Lung Injury; chemically induced; metabolism; therapy; Animals; Animals, Newborn; Liquid Ventilation; methods; Oleic Acid; toxicity; Swine; Tumor Necrosis Factor-alpha; blood; metabolism
- From: Chinese Medical Journal 2012;125(1):123-128
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDPediatric patients are susceptible to lung injury. Acute lung injury in children often results in high mortality. Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models. This study was designed to examine the hypothesis that PLV would attenuate the production of local and systemic tumor necrosis factor (TNF)-α in an immature piglet model of acute lung injury induced by oleic acid (OA).
METHODSTwelve Chinese immature piglets were induced acute lung injury by OA. The animals were randomly assigned to two groups of six animals, (1) conventional mechanical ventilation (MV) group and (2) PLV with 10 ml/kg FC-77 group.
RESULTSCompared with MV group, the PLV group had better cardiopulmonary variables (P < 0.05). These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/inspired O2 fraction (FiO2) and partial pressure of arterial carbon dioxide (PaCO2). PLV reduced TNF-α levels both in plasma and tissue compared with MV group (P < 0.05).
CONCLUSIONPLV provides protective effects against TNF-α response in OA-induced acute lung injury in immature piglets.
