ω-3PUFAs Prevent MK-801-induced Cognitive Impairment in Schizophrenic Rats via the CREB/BDNF/TrkB Pathway
10.1007/s11596-017-1762-4
- Author:
FANG MAO-SHENG
1
;
LI XING
;
QIAN HONG
;
ZENG KUAN
;
YE MENG
;
ZHOU YONG-JIE
;
LI HUI
;
WANG XIAO-CHUAN
;
LI YI
Author Information
1. Wuhan Mental Health Center
- Keywords:
schizophrenia;
MK-801;
ω-3 polyunsaturated fatty acids;
cognition impairment;
CREB/BDNF/TrkB pathway
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2017;37(4):491-495
- CountryChina
- Language:Chinese
-
Abstract:
This study was to determine the protective effect of ω-3 polyunsaturated fatty acids (ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia (SZ) rats and the underlying mechanism.A rat model of schizophrenia was induced by MK-801.The cognitive function of rats was assessed using a Morris water maze.The number of hippocampal neurons was measured by Nissl staining.The expression of CREB,p-CREB,BDNF,TrkB,p-TrkB,AKT,p-AKT,ERK,and p-ERK in the hippocampus of rats was detected by Western blotting.The results showed that ω-3PUFAs attenuated MK-801-induced cognitive,impairment and hippocampal neurons loss,reversed the injury of the CREB/BDNF/TrtB pathway induced by MK-801,and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats.In conclusion,ω-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT,thereby increasing the synaptic plasticity and decreashng neuron loss,and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.
