Trisomy 21 with t(5;11) Chromosomal Translocation as New Unfavorable Cytogenetic Abnormalities in Pediatric Acute Myeloid Leukemia Type M2: One Case Report of Nine-year Follow-up and Literature Review
10.1007/s11596-017-1809-6
- Author:
WANG LIN
1
;
WU XIAO-YAN
;
JIN RUN-MING
;
ZHANG BING-YU
;
QIU YI-NING
Author Information
1. Department of Pediatrics
- Keywords:
acute myeloid leukemia;
trisomy 21;
t(5;
11) chromosomal translocation;
prognosis
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2017;37(5):807-810
- CountryChina
- Language:Chinese
-
Abstract:
We report one case of pediatric acute myeloid leukemia type 2 (AML-M2) who presented with karyotypic aberration of trisomy 21 with the t(5;ll) chromosomal translocation.The patient achieved complete remission after two cycles of chemotherapy of daunorubicin,cytarabine and etoposide.Then,follow-up cytogenetic analysis from bone marrow cell cultures demonstrated a normal karyotype of 46,XY.After 9 years,the patient relapsed and the karyotypic abnormalities of trisomy 21 with t(5;ll) reappeared.It was concluded that trisomy 21 with t(5;11) is a new unfavorable cytogenetic aberration in AML-M2.
