Correlation between Survivin Expression and Laryngeal Carcinoma:A Meta-analysis
10.1007/s11596-017-1835-4
- Author:
GENG JUAN
1
;
LEI YAN-RONG
;
PEI SHENG-GUANG
Author Information
1. Department of Medical Records and Statistics
- Keywords:
Survivin;
laryngeal carcinoma;
prognosis;
meta-analysis
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2017;37(6):965-973
- CountryChina
- Language:Chinese
-
Abstract:
In order to provide evidence for evidence-based medicine in the treatment and prognosis of laryngeal cancer in China,the meta-analysis electronically retrieved the case-control studies published in China about the Survivin expression and its association with clinical pathological features in the tissues of laryngeal carcinoma.The results showed that a total of 25 case-control studies were finally included with 1333 cases of laryngeal cancer and 528 cases of controls.The difference in the expression of Survivin between the two groups was statistically significant [OR=18.34,95％ CI (11.82,28.47),P＜0.00001].The difference in the expression of Survivin between laryngeal carcinoma patients with lymph node metastasis or not was statistically significant [OR=0.25,95％ CI (0.17,0.37),P＜0.00001].The expression of Survivin in clinical Ⅰ-Ⅱ stage group was significantly lower than in the clinical stage Ⅲ-Ⅳ group [OR=0.24,95％ CI (0.18,0.32),P＜0.00001].The expression of Survivin in patients with low/medium differentiation was significantly lower than that in those with high differentiation [OR=0.33,95％ CI (0.26,0.43),P＜0.00001].The difference in the expression of Survivin among different T stages of laryngeal carcinoma was statistically significant [OR=0.35,95％ CI (0.21,0.58),P＜0.00001].In conclusion,Survivin may play an important role in the occurrence and development of laryngeal carcinoma,and its high expression is related to the poor prognosis of patients with laryngeal cancer.
