The experimental study of lipo-sodium morrhuate promoting apoptosis of ECV-304 cells.
- Author:
Zhuang-qun YANG
1
;
Hai-long LAN
;
Jun-bo TU
;
Yong SONG
;
Tie-liang ZHANG
;
Zhe XING
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; drug effects; Cell Proliferation; drug effects; Cells, Cultured; Endothelial Cells; pathology; Humans; Liposomes; Sodium Morrhuate; pharmacology; Umbilical Veins; cytology
- From: Chinese Journal of Stomatology 2007;42(3):188-189
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of lipo-sodium morrhuate on ECV-304 cell line.
METHODSThe effect lipo-sodium morrhuate was evaluated by toxicology trial (MTT), electron microscope, DNA electrophoresis and flow cytometer.
RESULTSThe toxicology results showed, that the number of vital cells in lipo-sodium morrhuate group decreased slowly. The electron microscope exhibited apoptosis in the lipo-sodium morrhuate group. And there were typical DNA ladder in DNA electrophoresis and typical apoptosis peak in flow cytometer. The apoptosis rate was 22.23%.
CONCLUSIONSUnlike the normal preparation of sodium morrhuate, lipo-sodium morrhuate could induce apoptosis of ECV-304 cell line.
