Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma.
- Author:
Zhan-gui TANG
1
;
Su-ping ZHAO
;
Lei ZHANG
;
Xiao-ling LI
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; genetics; Carcinoma, Verrucous; genetics; Gene Expression Profiling; Humans; Mouth Neoplasms; genetics; Oligonucleotide Array Sequence Analysis
- From: Chinese Journal of Stomatology 2007;42(4):229-230
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC).
METHODScDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile blotted and handled by bioinformation, the gene expression of these two kinds of lesions was examined.
RESULTSUsing the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the expression of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC.
CONCLUSIONSThe gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.
