Effect of fluorosis on the expression of basic fibroblast growth factor in rat incisors.
- Author:
Hui LIU
1
;
Qiang WANG
;
Feng ZHU
;
Ping-ping LUO
;
Tian-lin LIU
;
Xiao-ling WEI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Female; Fibroblast Growth Factor 2; metabolism; Fluorosis, Dental; metabolism; Incisor; metabolism; Male; Rats; Rats, Wistar
- From: Chinese Journal of Stomatology 2007;42(4):242-244
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of overdose fluoride on the expression of basic fibroblast growth factor (bFGF) in rat incisors.
METHODSTwenty Wistar rats were randomly divided into 2 groups: group I (control group) distilled water was given; group II (experimental group) 100 mg/L NaF was given. The rats were killed at the end of 8 th week. Immunohistochemical staining was used to study the expression of bFGF in rat incisors.
RESULTSImmunohistochemical results demonstrated the presence of bFGF in ameloblasts, odontoblasts of rat incisors. The expression of bFGF was reduced in group II (P < 0.01).
CONCLUSIONSOverdose fluoride inhibits the expression of bFGF and affects the interaction between dental epithelium and dental mesenchyme, which leads to the enamel demineralization.
