Relationship between tumor necrosis factor A-308 gene polymorphism and aggressive periodontitis.
- Author:
Xiao-Ling ZHU
1
;
Huan-Xin MENG
;
Li XU
;
Li ZHANG
;
Zhi-Bin CHEN
;
Dong SHI
Author Information
- Publication Type:Journal Article
- MeSH: Aggressive Periodontitis; genetics; Alleles; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymorphism, Genetic; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Stomatology 2007;42(5):268-271
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between tumor necrosis factor (TNF) A-308 gene polymorphism and aggressive periodontitis (AgP).
METHODSAnti-coagulated peripheral blood samples were obtained from 64 AgP patients, and 78 healthy controls (H). Genomic DNA was extracted from each sample. The TNF A-308 gene polymorphism was detected by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Data were analyzed by SAS statistical software.
RESULTSThere was no significant difference in distribution of TNF A-308 genotype between AgP patients and healthy controls. But the ORs for genotype GA and allele A were 22.2 and 16.1 respectively in non-smoking male AgP patients.
CONCLUSIONSThe TNF A-308 genotype GA and allele A may be associated with AgP susceptibility in Chinese males.
