Study on genetic aberrations of ocular mucosa-associated lymphoid tissue lymphomas occurring in southern China.
- Author:
Xue-mei ZHANG
1
;
Wen-yan ZHANG
;
Yuan-ping ZHOU
;
Xiang-lan MO
;
Yong-ping LI
;
Gui-qiu WANG
;
Ying-qiong ZHOU
;
Si-en ZENG
;
Gan-di LI
;
Hong-tao YE
Author Information
- Publication Type:Journal Article
- MeSH: Caspases; genetics; metabolism; China; Chromosome Aberrations; Chromosomes, Human, Pair 11; genetics; Chromosomes, Human, Pair 14; genetics; Chromosomes, Human, Pair 18; genetics; Chromosomes, Human, Pair 3; genetics; DNA-Binding Proteins; genetics; metabolism; Eye Neoplasms; genetics; metabolism; Humans; In Situ Hybridization, Fluorescence; Lymphoma, B-Cell, Marginal Zone; genetics; metabolism; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Neoplasm Proteins; genetics; metabolism; Proto-Oncogene Proteins c-bcl-6; Translocation, Genetic; Trisomy
- From: Chinese Journal of Pathology 2010;39(8):513-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the genetic aberrations of ocular extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type occurring in patients from southern China.
METHODSFifty seven paraffin-embedded ocular MALT lymphoma specimens from patients in southern China were studied by interphase fluorescence-in-situ hybridization (FISH) for genetic aberrations including t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/IgH-bcl-10, t(14;18) (q32;q21)/IgH-MALT1 and bcl-6/FOXP1 gene translocations.
RESULTSAmongst the 57 cases studied, 9 cases (15.8%) showed chromosome translocations, including 4 cases (7.0%) of t(11;18)(q21;q21)/API2-MALT1, 1 case (1.8%) of t(14;18) (q32;q21)/IgH-MALT1, 1 case (1.8%) of bcl-6 gene-related chromosome translocation and 3 cases (5.3%) of IgH-unknown translocation partner. FISH revealed 17 cases (29.8%) with 3 copies of bcl-6 gene, 21 cases (36.8%) with 3 copies of MALT1 gene and 12 cases (21.1%) with 3 copies of both genes.
CONCLUSIONSThe MALT lymphoma-associated chromosome translocations t(11;18)(q21;q21)/API2-MALT1 and t(14;18) (q32;q21)/IgH-MALT1 are demonstrated in ocular MALT lymphomas of southern Chinese patients. The prevalence is significantly different from that reported in northern Chinese and northern American patients, indicating a geographic heterogeneity in the MALT lymphoma-associated genetic aberrations. The presence of 3 copies of bcl-6 and MALT1 genes is the commonest genetic abnormalities observed in ocular MALT lymphomas, suggesting a possible role in MALT lymphomagenesis.
