Function of intersectin in endocytosis and exocytosis.
- Author:
Chun-Ying TIAN
1
;
Chun-Ling ZHANG
;
Feng GU
;
Yong-Jie MA
Author Information
1. Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Vesicular Transport;
physiology;
Endocytosis;
Exocytosis;
Humans;
Synaptic Vesicles;
physiology
- From:
Acta Physiologica Sinica
2012;64(4):489-494
- CountryChina
- Language:Chinese
-
Abstract:
Intersectin is an evolutionarily conserved multifunctional adaptor protein with multifunctional domains. These domains interact with components of the endocytic and exocytic pathways, such as the clathrin mediating synaptic vesicle recycling, the protein related to endocytosis via caveolae, the with-no-lysine kinases related to the regulation of renal outer medullar potassium, and the Cdc42 mediating exocytic pathway. Recently, the understanding of intersectin function in the pathogenesis of endocrine tumor and many neurodegenerative diseases such as Down syndrome, Alzheimer disease has been deepened. This article reviewed the structure and roles in endocytosis/exocytosis and diseases of intersectin.
