Electrical excitability of the apical dendrites of mammalian cortical pyramidal neurons.
- Author:
Shih-Fang FAN
1
Author Information
1. Former Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China. shihffan@gmail.com
- Publication Type:Journal Article
- MeSH:
Action Potentials;
Animals;
Dendrites;
physiology;
Electrophysiological Phenomena;
Ion Channels;
physiology;
Pyramidal Cells;
physiology;
Synaptic Transmission
- From:
Acta Physiologica Sinica
2012;64(6):707-712
- CountryChina
- Language:Chinese
-
Abstract:
The electrical excitability of the dendrites of the cortical neurons was first studied on the apical dendrites of the pyramidal neurons. Professor ZHANG Xiang-Tong (H-T Chang) made important contributions in the fifties of last century on this topic. Through numerous studies later on, it has been established that the electrical excitability of dendrites of different types of neurons, even different dendrites in the same neuron is different. For the apical dendrites of the cortical pyramidal neurons, neither a single nor a train of repetitive action potentials with constant frequency can reach its terminal portion. However, some of the burst repetitive responses with non-constant frequency of the apical dendrite elicited by direct current injected into the soma may reach the terminal portion. This may be due to: (1) the calcium ion concentration in the apical dendrite is increased by the burst activities, which, in turn, increases the electrical excitability of the apical dendrite and /or (2) some retrograde collaterals of axon of the activated soma reach the apical dendrite and release neurotransmitter glutamate, which changes the properties of the voltage-gated ion channels in the apical dendrite. Low electrical excitability of the apical dendrites seems to be essential for the processing of numerous income signals to the terminal portion of the apical dendrites.
