The influence of mitochondrial complex inhibition on neuronal ion channel and neurotransmitter release.
- Author:
Bin LAI
1
;
Ping ZHENG
Author Information
1. State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, China. laibin@fudan.edu.cn
- Publication Type:Journal Article
- MeSH:
Action Potentials;
Biological Transport;
Calcium Channels;
physiology;
Humans;
Ion Channels;
physiology;
Mitochondria;
physiology;
Neurodegenerative Diseases;
physiopathology;
Neurons;
physiology;
Neurotransmitter Agents;
physiology;
Potassium Channels;
physiology;
Sodium Channels;
physiology;
Synaptic Transmission
- From:
Acta Physiologica Sinica
2012;64(6):713-720
- CountryChina
- Language:English
-
Abstract:
Mitochondrial complex inhibition has been described in the pathophysiology of many neurodegenerative diseases, and the functional changes of neuron induced by mitochondrial complex inhibition and the mechanism are concerned. Neuronal function depends on action potentials and neurotransmitter release. Voltage dependent sodium/potassium ion channels mediate generation of neuron action potentials. And voltage dependent calcium ion channels are directly involved in the process of neurotransmitter release. The functional changes of those ion channels under some pathological conditions can induce neuron dysfunction, even death. Therefore, understanding the influence of mitochondrial complex inhibition on neuronal ion channels and neurotransmitter release is helpful to illuminate the pathophysiology of neurodegenerative diseases. This review will highlight recent progress in this field.
