Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions.
- Author:
Jia-Ming BIAN
1
;
Ning WU
;
Jin LI
Author Information
1. Department of Pharmacology, Military General Hospital of Beijing PLA, Beijing 100700, China.
- Publication Type:Journal Article
- MeSH:
Humans;
MAP Kinase Signaling System;
NF-kappa B;
physiology;
Neoplasms;
Phosphatidylethanolamine Binding Protein;
physiology;
Receptors, G-Protein-Coupled;
physiology;
Signal Transduction
- From:
Acta Physiologica Sinica
2013;65(2):237-243
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatidylethanolamine-binding protein (PEBP) is a cytoplasm soluble protein with a high conserved structure. It has been approved recently that PEBP is a multifunctional molecule regulating several important cellular signal pathways, including ERK cascade, NF-κB pathway, and signaling of G protein-coupled receptors. Furthermore, the role of PEBP in tumor metastasis also got a comprehensive attention in the field of clinical cancer research. Together, as a signal regulator at multiple paths in cell, PEBP is becoming a new focus in several research fields. This review is aimed to introduce the newest biological progress on PEBP.
