Diverse expression of ER-α36, a novel variant of ER-α, in hippocampus and cortex of neonatal and adult rats.
- Author:
Yang LIU
1
,
2
,
3
,
4
,
5
,
6
,
7
;
liujing.dlrmc@hotmail.com.
;
Chen FANG
;
Ping ZOU
;
Yi-Ni MA
;
Dan-Nv HAN
;
Zhi-Hong JI
;
Xiao-Feng LIANG
;
Xin GUAN
;
Liang HUANG
;
Tian FENG
;
Yi-Ting WANG
;
Jing LIU
;
Wei ZOU
Author Information
1. College of Life Science, Liaoning Normal University, Dalian 116081, China
2. The Research Center of Developmental and Educational Psychology, Liaoning Normal University, Dalian 116029, China
3. Regenerative Medicine Centre, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
4. Teacher's College, Dalian University, Dalian 116622, China
5. Medical College, Dalian University, Dalian 116622, China
6. School of Life Science, Fudan University, Shanghai 200433, China. E-mail: weizou60@126.com
7. liujing.dlrmc@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Cerebral Cortex;
metabolism;
Estrogen Receptor alpha;
metabolism;
Hippocampus;
metabolism;
Pyramidal Cells;
metabolism;
Rats;
Rats, Sprague-Dawley;
Signal Transduction
- From:
Acta Physiologica Sinica
2013;65(3):263-268
- CountryChina
- Language:Chinese
-
Abstract:
ER-α36, a novel variant of ER-α, is expressed in breast, uterus, digestive tract, respiratory tract etc. The aim of the present study was to investigate the distribution and expression of ER-α36 in the central nervous system (CNS). Here, we comparatively analyzed the expression pattern of ER-α36 in the hippocampus and cortex of neonatal (1-day-old) and adult (12-week-old) Sprague-Dawley (SD) rats by using immunohistochemistry/immunocytochemistry analysis and Western blot. The results showed that ER-α36 was expressed both in hippocampus and cortex of adult rats, but mainly distributed in pyramidal neurons. ER-α36 was mainly located on the cytomembrane of hippocampal and cortical neurons from neonatal rats. Compared with the cortical neurons, the hippocampal neurons showed lower ER-α36 protein expression in the neonatal rats, but exhibited higher level of ER-α36 in the adult rats. Furthermore, the adult rats showed higher levels of ER-α36 expression in both hippocampus and cortex compared with the neonatal rats. These results suggest that ER-α36 might be involved in the regulation of membrane-initiated estrogen signaling throughout the postnatal development of diverse brain regions, and thus will be a potential target for the treatment of degenerative diseases in nervous system.
