Preliminary study on genotype of hepatitis B virus detected from Tibetans in China.
- Author:
Yan-qing XU
1
;
Yong-dong ZHOU
;
Sheng-li BI
Author Information
- Publication Type:Journal Article
- MeSH: Genotype; Hepatitis B; blood; epidemiology; virology; Hepatitis B Core Antigens; genetics; Hepatitis B Surface Antigens; blood; genetics; Hepatitis B virus; classification; genetics; immunology; Humans; Phylogeny; Tibet; epidemiology
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(2):118-120
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the main genotype of hepatitis B virus (HBV) detected from Tibetans in China and provide basic data for hepatitis control and prevention.
METHODSThe S gene and C gene were amplified by PCR from the sera of HBsAg positive Tibetans. After sequencing, the gene sequences were analyzed and the phylogenetic trees were drawn by the software MEGA3.
RESULTSIn trees based on S gene, the sequences of most samples clustered at genotype D, while in trees based on C gene, the sequences of all samples clustered at genotype C.
CONCLUSIONThe dominant genotype of HBV detected from Tibetans in China is a C/D hybrid.
