Effects of HCMV on phenotypes of parotid duct epithelial cells and its mechanisms.
- Author:
Guo-rong YANG
1
;
Gao-sheng HUANG
;
Hai BAI
;
En-hua WANG
;
Ji-ye SONG
;
Ying GUO
;
Juan-hong WANG
;
Rong LIANG
;
Zhe WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antigens, CD; analysis; Antigens, Differentiation, Myelomonocytic; analysis; Antigens, Viral; analysis; Cathepsin D; analysis; Cytomegalovirus; immunology; physiology; Cytomegalovirus Infections; metabolism; pathology; virology; Desmin; analysis; Epithelial Cells; metabolism; pathology; virology; Female; Glial Fibrillary Acidic Protein; analysis; Host-Pathogen Interactions; Humans; Immunohistochemistry; Infant; Keratins; analysis; Male; Mice; Salivary Ducts; metabolism; pathology; virology; Vimentin; analysis
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(2):132-134
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of HCMV infection on phenotypes of parotid duct epithelial cells and relative mechanisms.
METHODSThe expressions of immediate early antigen of HCMV, pan cytokeratin and cathepsin D etc. were detected by immunohistochemical staining in tissues of parotid cytomegalic inclusion disease.
RESULTSCytokeratin which acts as an epithelial marker became negative while staining of Cathepsin D was intensified in parotid duct epithelial cells after infected by HCMV.
CONCLUSIONIt demonstrated that cytokeratin was lost through over-expression of Cathepsin D in parotid duct epithelial cells infected by HCMV.
