Nitric oxide and nitric oxide synthase in patients with chronic hepatitis B.
- Author:
Kai WANG
1
;
Li-yan HAN
;
Qin LU
;
Bing WANG
;
Xin-he LI
;
Hui-min WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Alanine Transaminase; blood; DNA, Viral; genetics; Female; Genotype; Hepatitis B virus; genetics; Hepatitis B, Chronic; blood; metabolism; virology; Humans; Male; Middle Aged; Nitric Oxide; metabolism; Nitric Oxide Synthase; metabolism; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate nitric oxide (NO) and nitric oxide synthase (NOS) in patients with chronic hepatitis B.
METHODSNitric oxide and nitric oxide synthase, including inducible NOS (iNOS) and constitutive NOS (cNOS), were measured in patients and control groups, then were statistically analyzed.
RESULTSNO and iNOS were significantly higher in patients with hepatitis B than in the controls (P < 0.05). NO and iNOS were significantly higher in patients with increased ALT than in the controls and in patients with normal ALT (P < 0.05). NO was significantly higher in patients with normal ALT than in the controls (P < 0.05). cNOS were not significant different among these groups. NO and iNOS significantly correlated with ALT in patients with hepatitis B (r=0.367 and r=0.474). No significant relationship was found among NO, NOS and HBV DNA. Among different genotype groups, NO and NOS had no significant difference.
CONCLUSIONNO and NOS were higher in patents with chronic hepatitis B. In patients with increased ALT, NO's damage was severe. In patients with normal ALT, there was no significant damage caused by NO. NO should be detected in patients with hepatitis B in addition to HBV markers.
