Soluble tumor necrosis factor related apoptosis inducing ligand (sTRAIL) and clinical outcome of HBV infection in human.
- Author:
Feng-e YUE
1
;
Dian-yong LIU
;
Jing SONG
;
Li-ning ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Alanine Transaminase; blood; Aspartate Aminotransferases; blood; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis B; blood; Hepatitis B, Chronic; blood; Humans; Liver Cirrhosis; blood; virology; Liver Neoplasms; blood; virology; Male; Middle Aged; Serum Albumin; analysis; TNF-Related Apoptosis-Inducing Ligand; blood; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(2):146-148
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of sTRAIL in the pathogenesis of HBV infection in human being.
METHODSsTRAIL in 153 patients' sera was examined with ELISA. Correlations between sTRAIL and liver functional parameters were analysed.
RESULTSThe levels of sTRAIL in patients with various clinical types of hepatitis B as well as primary hepatocellular carcinoma were all higher than that in normal persons and became almost normal in recovering stage cases. In acute and chronic HBV infection, sTRAIL level was negatively correlated with ALT, AST and total bilirubin levels, and positively correlated with serum albumin.
CONCLUSIONThe results indicated that higher level of sTRAIL expression is correlated with liver damage, and apoptosis induced by sTRAIL is one of the mechanisms of liver damage in HBV infection.
