Immunohistochemical evidence for HIV-1 infection in the liver of HIV-infected patients.
- Author:
Tian-jun JIANG
1
;
Min ZHAO
;
Jing-min ZHAO
;
Guang-de ZHOU
;
Deng PAN
;
Jian WANG
;
Yun-hui ZHANG
;
Zhi-ping ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; HIV Core Protein p24; biosynthesis; HIV Infections; metabolism; virology; HIV-1; physiology; Hepatocytes; metabolism; pathology; Host-Pathogen Interactions; Humans; Immunohistochemistry; Liver; metabolism; pathology; virology; Male; Middle Aged
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(2):152-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect p24 antigen of human immunodeficiency virus (HIV)-1 in the liver biopsy specimens of patients with HIV infection.
METHODSLiver biopsy samples from 14 patients with HIV/AIDS (11 man, 3 women; age range 27-52 years; infection time range 8-13 years) were examined by immunohistochemistry prospectively.
RESULTSIntracellular expression of HIV-1 p24 antigen was detected in Kupffer cells, endothelial cells and hepatocytes. There were more HIV-positive liver cells in the patients with severer liver damage than those with milder liver damage (t=2.5189, P=0.0270).
CONCLUSIONThese findings indicate that HIV-1 could replicate in the liver of HIV-infected patients and might be related to the liver cells apoptosis.
