Preliminary study on nasal spray of interferon alpha-2b used for prevention of rubella and measles virus infections.
- Author:
Jing ZHAO
1
;
Feng-cai ZHU
;
Yue-long SHU
;
Rui ZHOU
;
Li-qi LIU
;
Li-lan ZHANG
;
Zhi-yang SHI
;
Zhen TANG
;
Li-zhuo LIN
;
Zhi-ai YU
;
Li-ping ZHANG
;
Bin ZHANG
;
Yun-de HOU
Author Information
- Publication Type:Clinical Trial
- MeSH: Administration, Intranasal; Adult; Antibodies, Viral; blood; Antiviral Agents; administration & dosage; therapeutic use; Female; Humans; Interferon-alpha; administration & dosage; therapeutic use; Male; Measles; immunology; prevention & control; virology; Measles Vaccine; immunology; therapeutic use; Measles virus; drug effects; immunology; Recombinant Proteins; Rubella; immunology; prevention & control; virology; Rubella Vaccine; immunology; therapeutic use; Rubella virus; drug effects; immunology; Treatment Outcome; Vaccination; methods; Vaccines, Attenuated; immunology; therapeutic use; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(3):220-222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of the interferon alpha-2b nasal spray in prevention of rubella and measles virus infections.
METHODSThe properly selected volunteer groups have been divided into interferon alpha-2b experimental and control group. The experimental group received interferon alpha-2b treatment by nasal spray for 2 days before the immunization, then both groups were challenged with rubella and measles attenuated live vaccine respectively through nasal spray. The sera from pre-immunization and 21 and 28 days after immunization were collected to test the IgG antibody titers. The influence on the viral antibody titer reflects the viral preventive effect by interferon alpha-2b.
RESULTSThe antibody titer difference of measles virus between experimental and control group was 1.26 (21 day) and 2.96 (28 day), there were statistically difference between them; the difference of rubella virus was 0.95 (21 day) and 0.37 (28 day), but there were no statistically differences found.
CONCLUSIONThe preliminary results showed that the interferon alpha-2b can be used as prevention method for measles and rubella viral infections.
