Correlation of pathology in chronic hepatitis B to viral markers in serum and hepatic tissue.
- Author:
Jing HE
1
;
Shao-jie XIN
;
Jing-min ZHAO
;
Song-shan WANG
;
Shao-li YOU
;
Zheng-sheng ZOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Child, Preschool; DNA, Viral; blood; genetics; Female; Hepatitis B Core Antigens; blood; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Hepatitis B virus; genetics; immunology; physiology; Hepatitis B, Chronic; blood; pathology; virology; Host-Pathogen Interactions; Humans; Infant; Infant, Newborn; Liver; pathology; virology; Male; Middle Aged; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(3):264-266
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation of the viral markers in serum and those expressed by hepatocytes to pathological lesions of hepatic tissue in patients with chronic hepatitis B.
METHODSThe relation of viral markers including HBsAg, HBsAb, HBeAg, HBeAb, HBcAb and HBV DNA in serum of 647 patients with chronic hepatitis B and HBsAg, HBcAg expressed by hepatocytes in 418 of these patients to pathological lesions of hepatic tissue was determined.
RESULTSViral markers in serum and those expressed by hepatocytes in patients with chronic hepatitis B were closely correlated with pathological lesions of hepatic tissue.
CONCLUSIONThe degree of inflammation and fibrosis in hepatic tissue is milder in serum HBsAg, HBeAb, HBcAb positive and HBV DNA negative patients but more serious in those with negative hepatocytic expression of HBsAg and HBcAg. HBV DNA is not significantly associated with pathological lesions of hepatic tissue.
