Study on treatment effectiveness and safety in children with chronic hepatitis B or C using bicyclo tablets.
- Author:
Hong-fei ZHANG
1
;
Xiao-jin YANG
;
Shi-shu ZHU
;
Zhi-qiang XU
;
Yi DONG
;
Da-wei CHEN
;
Wen-zheng JIA
;
Yu GAN
;
Li-min WANG
;
Hong-mei TANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Biphenyl Compounds; adverse effects; therapeutic use; Child; Child, Preschool; Hepatitis B, Chronic; drug therapy; Hepatitis C, Chronic; drug therapy; Humans; Tablets; Treatment Outcome
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(4):380-382
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo evaluate treatment effectiveness and safety of bicyclo tablets in children with chronic hepatitis B or C.
METHODSA randomized controlled trial was conducted in 148 children with chronic hepatitis B or C for evaluating safety, tolerability, and efficacy of treatment with bicyclo tablets or Hugan tablets. Children in therapy group were treated with bicyclo tablets and control group treated with Hugan tablets.
RESULTS(1) ALT and AST level decreased more prominently in therapy group than in control group (P<0.01). (2) Bicyclo was more effective than Hugan tablets (P<0.01). (3) Symptoms were ameliorated more prominently in bicyclo group than in control group (P<0.01). (4) Both groups had no significant adverse events.
CONCLUSIONSatisfactory therapeutic effect and safety were obtained with bicyclo tablets in children with chronic hepatitis B or C.
