Antiviral therapy of chronic hepatitis B patients resistant to lamivudine.
- Author:
Su-nan CUI
1
;
Ming-ming WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Antiviral Agents; therapeutic use; DNA, Viral; blood; genetics; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B Antibodies; blood; Hepatitis B e Antigens; immunology; Hepatitis B virus; drug effects; genetics; immunology; Hepatitis B, Chronic; drug therapy; virology; Humans; Interferon-alpha; therapeutic use; Lamivudine; pharmacology; therapeutic use; Male; Middle Aged; Recombinant Proteins; Thymosin; therapeutic use; Treatment Outcome
- From: Chinese Journal of Experimental and Clinical Virology 2005;19(4):395-397
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo evaluate the efficacy of alpha-2b interferon alone or combined with alpha1-thymosin in treatment of patients with chronic hepatitis B (CHB) resistant to lamivudine.
METHODSSixty six patients with CHB resistant to lamivudine were enrolled and randomized into treatment group A, treatment group B and control group. In the treatment group A 26 cases, after giving interferon-alpha alone for 1 month, lamivudine was withdrawn and continuously treated with interferon-alpha for 5 months. In the treatment group B 10 cases, after treatment with interferon-alpha and thymosin-alpha1 for 1 month, lamivudine was withdrawn and continuously treated with interferon-alpha and thymosin-alpha1 for 5 months. In control group (30 cases), after lamivudine was directly withdrawn, no anti-virus drug was given. Hepatic function tests and serum virological index were detected at regular intervals in all patients.
RESULTSNormalization rate of hepatic function, HBV DNA seroconversion rate and HBeAg/HBeAb seroconversion rate in two treatment groups were significantly higher than those in control group.
CONCLUSIONThe study suggested that interferon-alpha alone or combined with thymosin-alpha1 in treatment of patients with chronic hepatitis B resistant to lamivudine showed a beneficial effect.
