Hypertonic saline solution resuscitation in hemorrhagic shock dogs.
- Author:
Xiujun CAI
1
;
Diyu HUANG
;
Yiping MU
;
Shuyou PENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Pressure; Blood Volume; Body Weight; Dogs; Electrolytes; blood; Female; Male; Resuscitation; Saline Solution, Hypertonic; administration & dosage; Shock, Hemorrhagic; physiopathology; therapy
- From: Chinese Journal of Traumatology 2002;5(3):180-185
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo find out the optimal concentration, infusion rate and dosage of saline for resuscitation.
METHODSForty-five dogs were used to establish hypovolemic shock models. The dogs were resuscitated with saline of different concentrations and different dosages under different infusion rates, and the resuscitation results were compared.
RESULTSThe best concentration was 7.5%, the best rate of infusion 20 ml/min (a volume equivalent to 15% of the shed blood) and the best dosage 5.71 ml/kg. The method was effective for resuscitation, the mean arterial pressure (MAP) could be elevated to 89% of the baseline, and this MAP could be kept for more than one hour.
CONCLUSIONSUsing 7.5% sodium chloride solution equivalent to 15% of the shed blood at an infusion rate of 20 ml/min can achieve a best resuscitation result.
