Effects of Ginsenoside Rb1 on proliferation of Schwann cells in culture.
- Author:
Xitang HU
1
;
Xiaoxiang CHEN
;
Liangjian XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Division; drug effects; physiology; Cells, Cultured; Dose-Response Relationship, Drug; Ginsenosides; adverse effects; pharmacology; Immunohistochemistry; Nerve Regeneration; drug effects; Probability; Rats; Rats, Inbred Strains; Schwann Cells; drug effects; physiology; Sciatic Nerve; cytology; physiology; Sensitivity and Specificity
- From: Chinese Journal of Traumatology 2002;5(6):365-368
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells in culture.
METHODSApplying MTT assay and Thymidine incorporation assay, the effects of Ginsenoside Rb(1) on the proliferation of Schwann cells isolated from the sciatic nerve of adult rat were studied.
RESULTSGinsenoside Rb(1) (10 microg/ml) significantly induced Schwann cell proliferation, the effect was similar to NGF (50 microg/ml). At high concentrations of Ginsenoside Rb(1) (1 mg/ml), the proliferation of Schwann cells was significantly inhibited.
CONCLUSIONSGinsenoside Rb(1) at the optimal concentrations is found to be effective in inducing the proliferation of Schwann cells, but at higher concentrations the drug is cytotoxic for Schwann cells.
