Anti-infective reconstituted bone xenograft used for primary bone grafting to repair contaminated defect in the radius in dogs.
- Author:
Zhi YUAN
1
;
Li ZHAO
;
Yun-Yu HU
;
Jian LIU
;
Liang SUN
;
Dan LI
;
Kai LIAN
;
Rong LU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Transplantation; methods; Cattle; Colony Count, Microbial; Dogs; Gentamicins; administration & dosage; Postoperative Complications; prevention & control; Radiography; Radius; diagnostic imaging; surgery; Staphylococcal Infections; prevention & control; Transplantation, Heterologous
- From: Chinese Journal of Traumatology 2003;6(2):86-90
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the effect of anti-infective reconstituted bone xenograft as a primary graft to repair a segmental with severe contamination.
METHODSA canine model of contaminated defect of 1.5 cm in size in the radius was used, in which anti-infective reconstituted bone xenograft or reconstituted bone xenograft was implanted as a primary graft followed by internal fixation. The effectiveness of the two grafting materials in repairing a contaminated segmental defect was compared.
RESULTSThe animals which had received implant of anti-infective reconstituted bone xenograft should largely healed defects 6 months after operation while the defects implanted with reconstituted bone xenograft remained unrepaired with bone infection.
CONCLUSIONSBesides its strong osteoinductive and osteoconductive activity, anti-infective reconstituted bone xenograft is highly antibacterial and can be used as a primary graft to repair the severely contaminated segmental defect.
