Effect of thyrotropin-releasing hormone on cerebral free radical reactions following acute brain injury in rabbits.
- Author:
Guang-Ming NIU
1
;
Xiu-Juan GU
;
Yu-Lin SU
;
Feng WAN
;
Fang-Zhong SU
;
De-Lin XUE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Edema; etiology; prevention & control; Brain Injuries; complications; metabolism; Female; Free Radicals; metabolism; Intracranial Pressure; Lipid Peroxidation; Male; Rabbits; Superoxide Dismutase; metabolism; Thyrotropin-Releasing Hormone; pharmacology
- From: Chinese Journal of Traumatology 2003;6(2):104-106
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the early effect of thyrotropin-releasing hormone (TRH) on cerebral free radical reactions after acute brain injury in rabbits.
METHODS30 healthy white rabbits were randomly divided into three groups: Group A (n=10), Group B (n=12) and Group C (n=8). The rabbits in Group A and Group B were injured by direct hit. At 0.5-4 hours after injury, the rabbits in Group A were injected with TRH (8 mg/kg body weight) through a vein and the rabbits in Group B were injected with normal saline of equal volume. The rabbits in Group C served as the normal control. Then all the rabbits were killed and brain tissues were obtained. The content of lipoperoxide (LPO), the activity of superoxide dismutase (SOD) and the water content of the brain tissues were measured.
RESULTSThe contents of LPO and water in brain tissues in Group A were lower and the activity of SOD was higher than those of Group B (P<0.05). After injury, intracranial pressure (ICP) rose rapidly and continuously with time passing by. When TRH was given to the animals in Group A, the rising speed of ICP slowed down significantly.
CONCLUSIONSTRH can decrease the cerebral free radical reactions and cerebral edema after acute brain injury in rats.
