Correlation between the Severity of Bone Pain and the Amount of CD34+ Cells after Peripheral Blood Stem Cell Mobilization.
10.17945/kjbt.2015.26.2.123
- Author:
Ji Weon SEO
1
;
Ji Seon CHOI
;
Yang Hyun KIM
;
Sung Soo YOON
;
Seonyang PARK
;
Kyou Sup HAN
Author Information
1. Department of Laboratory Medicine, Armed Forces Daegu Hospital, Gyeongsan, Korea.
- Publication Type:Original Article
- Keywords:
Peripheral blood stem cell;
Bone pain;
G-CSF;
CD34 positive cell;
Side effect
- MeSH:
Blood Component Removal;
Granulocyte Colony-Stimulating Factor;
Hematopoietic Stem Cell Mobilization*;
Humans;
Leukapheresis;
Neutrophils;
Stem Cells*;
Tissue Donors
- From:Korean Journal of Blood Transfusion
2015;26(2):123-131
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Peripheral blood stem cells (PBSCs) are mobilized by granulocyte-colony stimulating factor (G-CSF), which causes several side effects in allogeneic donors. We report on side effects of G-CSF administration and determine which side effects could be used in predicting the amount of harvested CD34+ cells. METHODS: Data from the first PBSC collections of 155 healthy donors between 2007 and 2010 were analyzed. Side effects were assessed using adverse event inventory, which was graded from 1 (mild) to 3 (severe) or 4 (disabling). RESULTS: G-CSF administration caused an elevation of WBC counts (mean 44,834/microL) and 86% of them were neutrophils. The mean mononuclear cells in apheresis products was 6.6x10(8)/kg and mean CD34+ cells was 6.0x10(6)/kg. Bone pain was reported by 151 healthy donors (97%) and severe bone pain was related to more CD34+ cells in apheresis products (P=0.041): 39 for grade 1 (5.1x10(6) CD34+cells/kg), 86 for grade 2 (6.0x10(6)), and 26 for grade 3 (7.1x10(6)). In addition, the percentage of collecting more than 5.0x10(6) CD34+cells/kg during the first leukapheresis showed correlation with the severity of bone pain. CONCLUSION: Bone pain was the most common side effect of G-CSF mobilization and more CD34+ cells were harvested in cases of severe bone pain.
