Correlation of HLA-A, B, DRB1 genes with leukemia.
10.7534/j.issn.1009-2137.2013.02.005
- Author:
Ying DU
1
;
Xiao-lan LIANG
;
Qian LI
;
Wen-jie WU
;
Jian LIU
;
Le-jing SUN
;
Lu-gui QIU
Author Information
1. Union Stem Cell & Gene Engineering Co. Ltd., Tianjin, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Alleles;
Case-Control Studies;
Child;
Child, Preschool;
Female;
Fetal Blood;
Gene Frequency;
Genotype;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
HLA-DRB1 Chains;
genetics;
Humans;
Infant, Newborn;
Leukemia;
genetics;
Middle Aged;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(2):285-288
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the correlation between HLA gene distribution and allele frequency of the patients with leukemia. PCR-SSP technique was used to detect the HLA genotype of 2994 umbilical cord blood units from healthy newborns (as control), the detecting result of which was compared with HLA genotypes of 1246 patients with leukemia searched in our cord blood bank. The differences between two groups were compared and analyzed. The results indicated that as compared with the control group, the allele frequencies of HLA-B*56 (0.56%), B*70 (0.24%) obviously increased (RR = 2.2546, 6.2598, χ(2) = 5, 5.98, P < 0.05), while the allele frequencies of HLA-A*03 (3.45%), A*30 (4.86%), B*13 (8.75%), B44* (3.25%), B61* (5.70%), DRB1*07 (8.23%), DRB1*15 (14.21%) obviously decreased in patients with leukemia (RR = 0.5889, 0.7187, 0.7359, 0.5713, 0.7127, 0.6242, 0.7976, χ(2) = 19.23, 9.82, 14.33, 20.48, 11.99, 33.21, 11.56, P < 0.01). It is concluded that HLA-B*56, B*70 alleles seem to be characterized by the genetic susceptibility to leukemia and may be served as risk markers for leukemia occurrence, while the HLA-A*03, A*30, B*13, B*44, B*61, DRB1*07, DRB1*15 can be considered as genetic indicators for resistance of leukemia.
