Expression of PD-L1 in lymphoma and its effect on lymphoma proliferation and chemotherapy resistance.
10.7534/j.issn.1009-2137.2013.02.022
- Author:
Yi LI
1
;
Jing WANG
;
Xiao-Yan KE
Author Information
1. Department of Hematology and Lymphoma Research Center, Peking University Third Hospital, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
B7-H1 Antigen;
metabolism;
Cell Line, Tumor;
Cell Proliferation;
Cisplatin;
pharmacology;
Drug Resistance, Neoplasm;
Lymphoma;
drug therapy;
metabolism;
pathology;
Mice;
Mice, Inbred BALB C;
Mice, Inbred C57BL
- From:
Journal of Experimental Hematology
2013;21(2):366-370
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the effect of PD-L1 on lymphoma cell proliferation and chemotherapy resistance, and explore a new and promising approach for therapy of lymphomas. The level of PD-L1 expression in tissues of patients with lymphoma and cell lines were detected by immunohistochemistry and flow cytometry. Both the stable high-PDL1-A20 cell strain and low-PDL1-A20 cell strain were sorted by flow cytometry, then inoculated into BALB/c mice as to establish a lymphoma bearing mouse model for observing tumor genesis. Finally, the effect of PD-L1 on routinely chemotherapy drug-cisplatin were observed. The results showed that the PD-L1 highly and widely expressed in lymphoma tissue and cell strains, the stable high-PD-L1 cell strain sorted by flow cytometry have higher lymphoma genesis than that of low-PD-L1 cell strain. It is concluded that PD-L1 can promote lymphoma genesis, meanwhile the PD-L1 may resist effect of cisplatin on lymphoma cells through anti-apoptosis.
