Clinical and prognostic analysis of 101 cases of primary gastrointestinal non-Hodgkin's lymphoma.
10.7534/j.issn.1009-2137.2013.02.026
- Author:
Li-Na SONG
1
;
Xi-Nan CEN
;
Jin-Ping OU
;
Ze-Yin LIANG
;
Zhi-Xiang QIU
;
Wen-Sheng WANG
;
Wei-Lin XU
;
Yuan LI
;
Mang-Ju WANG
;
Yu-Jun DONG
;
Yue YIN
;
Yu-Hua SUN
;
Wei LIU
;
Qian WANG
;
Li-Hong WANG
;
Ying WANG
;
Han-Yun REN
Author Information
1. Department of Hematology, The First Hospital, Peking University, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Female;
Gastrointestinal Neoplasms;
diagnosis;
mortality;
pathology;
Humans;
Lymphoma, Non-Hodgkin;
diagnosis;
mortality;
pathology;
Male;
Middle Aged;
Neoplasm Staging;
Prognosis;
Survival Rate;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(2):387-391
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to analyze the clinical characteristics and prognostic factors in patients with primary gastrointestinal non-Hodgkin's lymphoma (PGI-NHL). The pathological data of 101 PGI-NHL patients admitted in our hospital in the past 15 years were analyzed retrospectively. The results showed that 101 patients with PGI-NHL accounted for 14.49% of NHL in the same period, there were 64 males, 37 females, the range of ages was from 18 to 87 years old, median age was 61 years old; in disease distribution, the stomach PGI-NHL accounted for 58.42%, intestine PGI-NHL accounted for 39.60%, multiple GI involvements (MGI) accounted for 1.98%; in pathological type, diffuse large B cell lymphoma (DLBCL) accounted for 66.34%, mucosa-associated lymphoid tissue (MALT) lymphoma accounted for 17.82%, mantle cell lymphoma (MCL) accounted for 3.96%, enteropathy-associated T cell lymphoma (EATL) accounted for 7.92%, extra-nodal nasal type NK/T cell lymphoma accounted for 1.98%, follicular lymphoma (FL) accounted for 0.99%, small lymphocyte lymphoma (SLL) accounted for 0.99%. Eighty-nine out of 101 patients were followed up (49 cases live, 40 cases dead), data of the 12 patients were lost; the median survival time was 29 months (1 - 173). The three-year OS and five-year OS were 58.4% and 52.6% respectively. Univariate analysis revealed that the factors affecting OS included sex (P = 0.004), lesion site (P = 0.002), tumor size (P = 0.011), clinical Lugano staging for gastrointestinal non-Hodgkin's lymphoma (P = 0.003), IPI score (P = 0.000), pathological cell phenotype (P = 0.001), and pathological type (P = 0.006), their differences were statistically significant (P < 0.05). Multivariate Cox regression analysis indicated that clinical Lugano staging for gastrointestinal non-Hodgkin's lymphoma, IPI score, pathological type were independent prognostic risk factors affecting OS. It is concluded that clinical Lugano staging for gastrointestinal non-Hodgkin's lymphoma, IPI score and pathological type are independent risk factors affecting OS.
