Expression and significance of p53-inducible gene 3 (PIG-3) in diffuse large B cell lymphoma.
10.7534/j.issn.1009-2137.2013.02.028
- Author:
Feng ZHU
1
;
Lu-Qin ZHANG
;
Wei-Jun GU
;
Wei ZHU
;
Yu-Lin GUO
Author Information
1. Department of Hematology, Xuzhou First People's Hospital, Xuzhou, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Case-Control Studies;
Female;
Humans;
Intracellular Signaling Peptides and Proteins;
genetics;
Lymphoma, Large B-Cell, Diffuse;
diagnosis;
genetics;
Male;
Middle Aged;
Prognosis;
Proto-Oncogene Proteins;
genetics;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(2):396-398
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the expression of p53-inducible gene 3 (PIG-3) in diffuse large B cell lymphoma (DLBCL) and the relationship between PIG-3 and the pathogenesis of lymphoma. The expression of PIG-3 in 20 patients with DLBCL and 20 healthy adults (as a control group) was detected by Western blot and RT-PCR. The results showed that the expression of PIG-3 protein in patients with DLBCL was significantly lower than that in controls, but the expression of PIG-3 was higher after chemotherapy for 6 months than that before chemotherapy. RT-PCR detection demonstrated that the size of PIG-3 amplified product is 1285 bp, which is coincident with theoretic value. It is concluded that the down-regulation of PIG-3 expression may be closely related to pathogenesis of DLBCL, so the PIG-3 gene can considered as a important marker for judging therapeutic efficacy and prognosis of patients with DLBCL.
