EB virus-associated lymphoproliferative disorders and cytokine storm.
10.7534/j.issn.1009-2137.2013.02.051
- Author:
Qian LIU
1
;
Ping ZHU
Author Information
1. Department of Hematology, Peking University First Hospital, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
immunology;
Disease Progression;
Epstein-Barr Virus Infections;
immunology;
Herpesvirus 4, Human;
Humans;
Lymphoproliferative Disorders;
immunology;
virology
- From:
Journal of Experimental Hematology
2013;21(2):498-502
- CountryChina
- Language:Chinese
-
Abstract:
Epstein-barr virus (EBV)-associated lymphoproliferative disorders (EBV-LPD) include a series of diseases from chronic to aggressive EBV-positive T-cells, NK cells, T/NK cells or B-cell LPD. The occurrence and development of EBV-LPD are closely associated with the cytokine storm, the clinical manifestations are very complex. Studies found that the different types of EBV-LPD express different cytokine secretion patterns, which help to further understand the progression of diseases, thus the EBV-LPD can be diagnosed early and treated early. In this article, different cytokine secretion patterns and their roles in EBV-LPD progression are reviewed. The main problems discussed above are the classification of EBV-LPD, T/NK-LPD and cytokine, B-LPD and cytokine, HLH and cytokine, and so on.
