Research progress of N-Myc roles in hematopoiesis and hematologic malignancies.
10.7534/j.issn.1009-2137.2013.02.052
- Author:
Li-Jing SHEN
1
;
Lan-Fang CAO
;
Fang-Yuan CHEN
Author Information
1. Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
Hematologic Neoplasms;
Hematopoiesis;
Humans;
Proto-Oncogene Proteins c-myc;
metabolism
- From:
Journal of Experimental Hematology
2013;21(2):503-507
- CountryChina
- Language:Chinese
-
Abstract:
N-Myc oncogene plays an important role in the process of hematopoietic cell proliferation and differentiation in embryos. Once the body suffers from hematologic malignancies, the expression of N-Myc would increase and significantly associate with disease progression. In this article the structure of N-Myc, the regulatory mechanism in the different hematopoietic lineages, the interaction in each signal pathways, the transgenic animal model of overexpression, and intervention by drugs are reviewed.
