Role of signal transducer and activator of transcription 3 in the development of tumors.
10.7534/j.issn.1009-2137.2013.02.055
- Author:
Chun-Sheng HAN
1
;
Yan CHEN
;
Xue-Qiang WU
Author Information
1. Institute of Hematology & Oncology, Beijing Aerospace General Hospital, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Neoplasms;
metabolism;
pathology;
STAT3 Transcription Factor;
Signal Transduction
- From:
Journal of Experimental Hematology
2013;21(2):517-520
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription 3 (STAT3) take part in cell proliferation, differentiation, survival, apoptosis, transformation, cellular immunity and some other important physiological and pathological processes. Among STAT3 signaling pathways, the JAK-STAT signaling pathway has been comprehensively studied. Abnormal activation of STAT3 is frequently detected in various tumors, and the abnormal activation is closely related with the tumorigenesis. Recent studies have found that mutations and several specific genotypes of single nucleotide polymorphisms in STAT3 gene may be involved in tumor formation, also suggesting the important role of STAT3 in tumor biology. In this review, the role of STAT3 in the development of tumors is briefly summarized.
