Influence of transplantation and some clinical factors on prognosis of patients with diffuse large B-cell lymphoma.
10.7534/j.issn.1009-2137.2013.03.017
- Author:
Shi-Xiang ZHAO
1
;
Yue HAN
;
Qian ZHU
;
Qian WANG
;
Wen-Juan ZHANG
;
Xiao-Chen CHEN
;
Ai-Ning SUN
;
Zheng-Ming JIN
;
Hui-Ying QIU
;
Xiao-Wen TANG
;
Zhen-Zhen FU
;
Guang-Sheng HE
;
Miao MIAO
;
Xiao MA
;
De-Pei WU
Author Information
1. Jiangsu Institute of Hematology, Soochow University First Affiliated Hospital, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Antibodies, Monoclonal, Murine-Derived;
Antineoplastic Combined Chemotherapy Protocols;
Cyclophosphamide;
Doxorubicin;
Female;
Hematopoietic Stem Cell Transplantation;
Humans;
Lymphoma, Large B-Cell, Diffuse;
diagnosis;
therapy;
Male;
Middle Aged;
Prednisone;
Prognosis;
Retrospective Studies;
Vincristine;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(3):623-627
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to analyze the survival status of patients with diffuse large B-cell lymphoma (DLBCL) and to investigate the influence of autologous hematopoietic stem cell transplantation (auto-HSCT), different pathological types, International Prognosis Idex (IPI) on prognosis. One hundred and sixteen cases of DLBCL were analyzed retrospectively. The treatment efficacy of R-CHOP alone and R-CHOP combined with auto-HSCT as well as the influence of different immunopathologic types, IPI, hypersensitive C-reactive protein (HSCRP), α-hydroxybutyric acid deaminase (HBDH) on the prognosis of DLBCL patients including overall survival (OS) rate, progression-free survival (PFS) rate were analyzed. The results indicated that the 5-year OS for all patients was 72.4%. in which 30 patients with Ann Arbor staging III-IV received auto-HSCT plus R-CHOP. The prognosis of the 30 patients was better than that of 86 cases received R-CHOP chemotherapy alone (5-year OS was 82.5% vs 69.0%, 5-year PFS was 77.1% vs 68.3%) (P < 0.05). The prognosis of patients in germinal center B-cell-like group (GCB group) was better than that of patients in activated B-cell-like group (ABC group). Some clinical features were associated with poor prognosis including OS and PFS, such as age, B symptoms, IPI scores, the level of LDH, HSCRP and HBDH (P < 0.05) in which the level of LDH, age ≥ 60 years and B symptoms were independent prognostic factors in DLBCL patients (P < 0.05). It is concluded that auto-HSCT combined with R-CHOP can improve the long-term survival of DLBCL patients. The prognosis of patients in GCB group is better than that of patients in the ABC group. The clinical features such as age, B symptoms, IPI scores and LDH are associated with prognosis.
