Diagnostic value of dysplasia characteristics in typing of myelodysplastic syndrome.
10.7534/j.issn.1009-2137.2013.03.024
- Author:
Jia LI
1
;
Man ZHANG
Author Information
1. Capital Medical University, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Bone Marrow;
pathology;
Erythroid Precursor Cells;
pathology;
Female;
Granulocyte Precursor Cells;
pathology;
Humans;
Male;
Megakaryocytes;
pathology;
Middle Aged;
Myelodysplastic Syndromes;
blood;
diagnosis;
pathology;
Sensitivity and Specificity
- From:
Journal of Experimental Hematology
2013;21(3):657-661
- CountryChina
- Language:Chinese
-
Abstract:
This study was purpose to investigate the diagnostic value of hematopoietic cell dysplasia in myelodysplastic syndrome (MDS). Sixty-four cases of WHO-MDS were detected by cytomorphology, cytohistochemical staining and bone marrow biopsy. The characteristics of hematopoietic cell dysplasia were analyzed, and its sensitivity and specificity were evaluated for WHO-MDS diagnosis. The results showed that though myeloblast, megakaryocytes presented in peripheral blood and granular Auer body, abnormal granular pseudo Pelger-Huër, vacuole of erythroid, micro-megakaryocytes appeared in bone marrow for diagnosis sensitivity were not very high, and respectively were 34.4%, 3.1%, 3.1%, 75.0%, 6.3%, 42.4%, the specificity of these characteristics was 100%. Moreover, erythroid odd nucleus, nuclear deformity, fragmentation, nuclear budding, ring sideroblasts, single and more round nuclear megakaryocyte had better reference value for WHO-MDS diagnosis. By bone marrow biopsy, the dysplasia and abnormal localization of immature precursor (ALIP) also were found in patients with WHO-MDS. More than half patients with WHO-MDS had mild to moderate increase in reticulin fibres. It is concluded that the cytomorphology assay is the base and key for the diagnosis of WHO-MDS. Diagnostic accuracy can be improved by combinative use of a variety of detection methods.
