Evaluation of a new method and instrument for detection platelet aggregation function and its clinical application.
10.7534/j.issn.1009-2137.2013.03.027
- Author:
You-Tao ZHANG
1
;
Yi-Ming ZHAO
;
Shun-Dong JI
;
Yun-Xiao ZHAO
;
Min JIANG
;
Xiao-Hua JIN
;
Jin-Fang SHI
;
Guo-Hao GU
;
Chang-Geng RUAN
Author Information
1. The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Female;
Humans;
Male;
Middle Aged;
Platelet Aggregation;
Platelet Function Tests;
instrumentation;
methods;
Young Adult
- From:
Journal of Experimental Hematology
2013;21(3):674-677
- CountryChina
- Language:Chinese
-
Abstract:
This study was purpose to evaluate a new method and instrument for detecting platelet aggregation function, establish the reference intervals for PL-11 platelet analyzer, and evaluate its clinical application. The evaluation was based on the guidelines of Clinical and Laboratory Standards Institute (CLSI or NCCLS) and Clinical Laboratory Improvement Amendment 88. Intravenous blood samples anticoagulated with sodium citrate were detected by PL-11 platelet analyzer. The reference intervals were defined after statistic analysis. The clinical diagnostic significance of the PL-11 platelet analyzer was evaluated by testing the change rate of platelet maximum aggregation rate (MAR) of acute cerebral infarction (ACI) patients in the department of Neurology who took clopidogrel 7 d before and after. The result showed that all the parameters meet the standard of CLIA'88. The platelet MAR of 247 healthy volunteers which was induced by PLR-06, PLR-07, PLR-09 and PLR-10, was detected by the PL-11 platelet analyzer, respectively. The MAR is 58.8 ± 10.1 (%), 61.2 ± 11.8 (%), 51 ± 10.2 (%), 53.1 ± 9.2 (%), respectively. The MAR of ACI patients is significantly lower than that after taking clopidogrel. It is concluded that the PL-11 platelet analyzer is an ideal platelet function detector for early warning and diagnosis of thromboembolic disease, which is worthy to be extended and applied.
