Relationship between HLA-A, B alleles and red blood cell parameters of patients with --(SEA/αα) subtype of α(0)-thalassemia of Han ethnic population of Wuzhou city.
10.7534/j.issn.1009-2137.2013.03.030
- Author:
Xiu-Qun CHEN
1
;
Jun LI
;
Yong-Lin CAI
;
Chuan-Jie LI
;
Yu-Yi MA
;
De-Wang HUANG
;
Hai-Feng LI
;
Ai-Ying LU
;
Min-Zhong TANG
Author Information
1. Wuzhou Red Cross Hospital, Guangxi Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Alleles;
Child;
Child, Preschool;
China;
epidemiology;
Erythrocytes;
cytology;
Ethnic Groups;
genetics;
Female;
Genotype;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
Hemoglobins, Abnormal;
genetics;
Humans;
Male;
Middle Aged;
Young Adult;
alpha-Thalassemia;
blood;
classification;
epidemiology;
genetics
- From:
Journal of Experimental Hematology
2013;21(3):688-691
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the relationship between HLA-A, B allele polymorphisms and red blood cell parameters of patients with --(SEA/αα) subtype of α(0)-thalassemia in Han ethnic population of Wuzhou city. The HLA genetic polymorphisms were determined by polymerase chain reaction-sequence-based typing (PCR-SBT) in 57 patients with --(SEA/αα) subtype of α(0)-thalassemia of Han ethnic population in Wuzhou city, Guangxi province, China. Mean corpuscular volume (MCV), hemoglobin (Hb), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were detected by automatic blood analyzer system. HbA2 were detected by electrophoretic method. The statistical analysis was performed by ordinal polytomous logistic regression. The results showed that Hb and HbA2 levels were significantly lower in patients positive for HLA-A*33:03, B*15:01 or B*55:02, and were significantly higher in patients positive for B*15:02 (P < 0.05). It is concluded that several HLA alleles may be associated with Hb level of --(SEA/αα) subtype of α(0)-thalassemia of Han ethnic population in Wuzhou city. This result has the value for understanding phenotype-genotype relationships in thalassemia.
