Effect of ghrelin on duodenal migrating myoelectric complex in rats with chronic renal failure.
- Author:
Rong-Guo FU
1
;
Li WANG
;
Jun ZHANG
;
Jian-Ping ZHOU
;
Gang-Lian YAO
;
Yan OU
;
Cai-Xia QI
;
Bao-Song GUI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Duodenum; drug effects; Gastrointestinal Motility; drug effects; Ghrelin; pharmacology; Kidney Failure, Chronic; physiopathology; Male; Myoelectric Complex, Migrating; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2011;31(4):624-627
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of ghrelin on duodenal migrating myoelectric complex (MMC) in rats with chronic renal failure (CRF).
METHODSThirty healthy male SD rats were randomly assigned into sham-operated group (n=6) and CRF group (n=24), and the latter group was divided into 4 subgroups according to ghrelin doses administered with or without pretreatment with the receptor antagonist D-Lys(3)-GHRP-6. After a 18-h fasting, the rats with or without pretreatment with D-Lys(3)-GHRP-6 were given subcutaneous injections of ghrelin at different doses to observe the changes in duodenal MMC recorded using a multi lead physiological recording system.
RESULTSGhrelin significantly increased the MMC cycle duration and dose-dependently enhanced the frequency, amplitude and percentage of phase III MMC cycle. This effect was inhibited by the pretreatment with ghrelin receptor antagonist D-Lys(3)-GHRP-6.
CONCLUSIONGhrelin can promote gastrointestinal motilities of rats with CRF, and the receptor of ghrelin can regulate the activity of MMC.
