Association of peripheral blood hypoxia-inducible factor-1α with metastasis of colorectal cancer.
- Author:
Chun-Qiu PAN
1
;
Shu-Ling HAN
;
Bi-Xiang YU
;
Can-Hui ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; blood; pathology; Adult; Aged; Aged, 80 and over; Case-Control Studies; Colorectal Neoplasms; blood; pathology; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; blood; genetics; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; RNA, Messenger; genetics
- From: Journal of Southern Medical University 2011;31(4):705-706
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between hypoxia-inducible factor-1α (HIF-1α) mRNA levels in the peripheral blood and the metastasis of colorectal cancer.
METHODSHIF-1α mRNA in the peripheral blood was detected by RT-PCR in 40 patients with colorectal cancer and 20 healthy subjects.
RESULTSSeventeen patients with colorectal cancer showed positivity for HIF-1α mRNA, showing a significantly higher positivity rate (42.5%) than the healthy subjects (P<0.05). The expression of HIF-1α mRNA is closely related to the staging of colorectal cancer (CRC).
CONCLUSIONHIF-1α mRNA may serve as a potential marker in the detection of metastasis of colorectal cancer.
